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1.
Phytochem Anal ; 20(4): 265-71, 2009.
Article in English | MEDLINE | ID: mdl-19333915

ABSTRACT

BACKGROUND: Investigations in the field of pharmaceutical analysis and quality control of medicines require analytical procedures that achieve suitable performance. An analytical curve is one of the most important steps in the chemical analysis presenting a direct relationship to features such as linearity. OBJECTIVE: This study has the aim of developing a new methodology, the stationary cuvette, to derive analytical curves by spectroscopy for drug analysis. METHODOLOGY: The method consists basically of the use of a cuvette with a path length of 10 cm, containing a constant volume of solvent in which increasing amounts of a stock solution of the sample are added, droplet by droplet. After each addition, the cuvette is stirred and the absorbance is measured. This procedure was compared with the currently used methodology, which requires a labour-intensive dilution process, and possible sources of variation between them were evaluated. RESULTS: The results demonstrated that the proposed technique presented high sensitivity and similar reproducibility compared with the conventional methodology. In addition, a number of advantages were observed, such as user-friendliness, cost-effectiveness, accuracy, precision and robustness. CONCLUSION: The stationary cuvette approach may be considered to be an appropriate alternative to derive analytical curves for analysing drug content in raw materials and medicines through UV-VIS spectrophotometry.


Subject(s)
Hydrocortisone/chemistry , Ibuprofen/chemistry , Kalanchoe/chemistry , Penicillin G Benzathine/chemistry , Plant Extracts/chemistry , Spectrophotometry/methods , Reproducibility of Results
2.
Pharm Dev Technol ; 12(5): 437-45, 2007.
Article in English | MEDLINE | ID: mdl-17963143

ABSTRACT

In this article, a nanosuspension of AmB was prepared and mixed with the preformed parenteral emulsion Lipofundin and subjected to high-pressure homogenization (SolEmuls technology). Characterization was performed by photon correlation spectroscopy (PCS), laser diffractometry (LD), and zeta potential measurements. Drug incorporation was studied by using light microscopy. The produced emulsions were further investigated by comparing them with the commercially available Fungizone in regard to antifungal efficiency and toxicity. Results suggest that through the SolEmuls process the AmB forms a reservoir, out of which it is released in such a manner that it is more efficient and less toxic than Fungizone.


Subject(s)
Amphotericin B/chemistry , Amphotericin B/pharmacology , Amphotericin B/administration & dosage , Candida tropicalis/drug effects , Drug Combinations , Drug Stability , Emulsions , Erythrocytes/drug effects , Erythrocytes/metabolism , Hemoglobins/metabolism , Lecithins/chemistry , Microbial Sensitivity Tests , Nanotechnology/methods , Particle Size , Phospholipids/chemistry , Potassium/metabolism , Solubility , Sorbitol/chemistry , Spectrophotometry , Static Electricity , Surface Properties , Suspensions/chemistry
3.
Int J Pharm ; 344(1-2): 158-60, 2007 Nov 01.
Article in English | MEDLINE | ID: mdl-17614224

ABSTRACT

The aim of this work was to investigate the influence of a lipophilic drug, Ibuprofen, on the stability of o/w emulsions. Five formulations were prepared by the phase inversion temperature (PIT) method, and Ibuprofen was incorporated into their oil phase. Emulsion stability was evaluated by short- and long-term studies. Concerning the former, stability under centrifugation showed an improved profile for Ibuprofen-loaded emulsions. The latter confirmed such findings. In conclusion, a rather resistant interfacial film may take place when Ibuprofen was incorporated into the emulsions. Therefore, the critical hydrophilic-lipophilic-balance (HLB) of o/w emulsions can be affected by a lipophilic drug into their oil phase. Such approach is of great importance on the development of lipid carriers for therapeutic drug targeting.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemistry , Drug Carriers/chemistry , Emulsions/chemistry , Ibuprofen/chemistry , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Drug Stability , Emulsifying Agents/chemistry , Hydrogen-Ion Concentration , Ibuprofen/administration & dosage , Mineral Oil/chemistry , Rheology , Water/chemistry
4.
Curr Pharm Des ; 13(11): 1179-85, 2007.
Article in English | MEDLINE | ID: mdl-17430178

ABSTRACT

Suboptimal disposition behavior of drugs requires innovative delivery approaches. Magnetic drug targeting seems to be a promising one. Magnetic particles develop magnetic polarization and magnetophoretic mobility, and because of such unique properties, these carriers may be eligible candidates for delivering drugs to specific locations within the body. Their special properties also allow other uses, such as those in magnetic separation, hyperthermia, and magnetic resonance imaging. This review focuses on a brief discussion of magnetic drug targeting, the properties and fate of magnetic carriers, the methods used to produce and characterize them, and their other uses in biotechnology.


Subject(s)
Drug Carriers/administration & dosage , Drug Delivery Systems/methods , Biotechnology/methods , Biotechnology/trends , Drug Delivery Systems/trends , Humans , Magnetics
5.
Rev. ciênc. farm. básica apl ; 27(1): 21-26, 2006. graf
Article in English | LILACS | ID: lil-458664

ABSTRACT

O objetivo desse trabalho foi o de desenvolver e avaliar do ponto de vista físico-químico um sistema micelar de penicilina G benzatina (BPG) em desoxicolato de sódio (NaDC).Foram estudadas as características físicoquímicas da BPG quanto à solubilidade em água e em soluções tampões com diferentes pHs, além do coeficiente de partição octanol-água.Foram avaliadas as propriedades da concentração micelar crítica (CMC) das soluções micelares de Desoxicolato de sódio (NaDC) em baixa e alta força iônica provocada pela presença de cloreto de sódio.O estudo da incorporação da BPG em soluções micelares de NaDC usando várias concentrações de NaDC também foi realizado.O aumento da solubilidade da BPG provocada pela presença de micelas de NaDC foi analisada quantitativamente pelo formalismo do modelo de pseudo-fase.Houve indicação da aplicabilidade do sistema micelar estudado quanto à incorporação de penicilina e aumento se sua solubilidade aparente, com taxa de incorporação de até 90 por cento.Espera-se que a formulação micellar de BPG apresente melhor estabilidade, considerando-se que o antibiótico incorporado na região hidrofóbica das micelas está protegido do meio aquoso externo.


Subject(s)
Penicillin G Benzathine/administration & dosage , Penicillin G Benzathine/pharmacology , Deoxycholic Acid , Drug Stability , Micelles , Solubility
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